The focus of our scientific activity is in the chemistry of boron clusters. Its geometric forms and the fact that they are made of a semi-metal, Boron, give them unique properties largely unexplored. Today, the chemistry of boron clusters, has achieved a sufficient degree of maturity that has led to new clusters. However, much emphasis has been given on finding new structures rather than on improving protocols of syntheses, the latter a necessary step in order to study their applications. So much emphasis has been given on generating new clusters that substitution reactions are in many cases in their infancy; for example, in generating bonds like B-C, B-P, or B-N, among others.