Among inorganic nanoparticles, superparamagnetic iron oxide nanoparticles (SPIONs) show great promise for medicine. In this work, we study in detail the formation, composition, and structure of a monolayer of bovine serum albumin (BSA) on SPIONs. We determine, both by molecular simulations and experimentally, that ten molecules of BSA form a monolayer of BSA around the SPIONs and their binding strength to the SPIONs is about 3.5×10–4 M, ten times higher than the adsorption of fetal bovine serum (FBS) on the same SPIONs. We elucidate a strong electrostatic interaction between BSA and the SPIONs, although the secondary structure of the protein is not affected. We present data that supports the strong binding of the BSA layer on SPIONs and the properties of the BSA layer as a protein-resistant coating. We believe that a complete understanding of the behavior and morphology of BSA-SPIONs and how the protein interacts with SPIONs is crucial for improving NP surface design and expanding the potential applications of SPIONs in nanomedicine.
El treball final de grau “TIO2/Au nanoparticles on bacterial cellulose substrates for photocatalytic applications” d’en Pol ha estat guardonat amb el Premi Xavier Domingo de la Universitat de Barcelona en la seva quarta edició. El Premi Xavier Domingo reconeix els millors treballs de final de grau sobre ciència de col·loides, cosmètica i detergència i està obert a tots els estudiants de les universitats espanyoles.
El lliurament del premi es farà el dia 4 de juliol a l’Hotel Crowne Plaza, coincidint amb l’acte inaugural del Formula VIII Congress of Formulation i les 46es Jornades anuals del Comité Español de la Detergencia, Tensioactivos y Afines.
Anna gave the presentation “Implications of surface coating SPIONs with a pre-form protein corona” at the HINT Workshop“Nanostructured materials: coatings, surface, bioceramics/-composites membranes” that has taken place in Vilnius, Lithuania 14-16th March 2016. She also participated in the Management Committee Meeting of this COST Action.
Today, 11 February, is the first International Day of Women and Girls in Science, a day created by the United Nations to emphasise the importance of women in science and to rise the gender equality in the scientific world. The women and girls from the N&N Group have participated in the celebration of this day, as you can see in the picture (enlarge here).
This first test using natural Mediterranean seawater has shown that the method and electrodes worked correctly.
Studies were done at the Institut de Ciències del Mar (ICM-CSIC) in the Aquaria and Experimental Chambers (ZAE) facilities.
The water salinity of the samples was ~38, that is, nearly the highest values (40) that can be found in open seas worldwide. Neither “recent” nor “old” seawater analysed showed significant values of Cd and Pb. However, Cu was detected in the “old” seawater. These results are in accordance to the periodic control analyses carried out in the ZAE.
Laura Asturias (NAPCOM-CSIC) and Jordi Salat (ICM-CSIC)
Laura has graduated from the ‘Màster en Direcció i Organització Industrial’ of EUSS – Escola Universitària Salesiana de Sarrià -. Her master thesis proposed a scale up fabrication process for iron oxide nanoparticles including a business plan. Yesterday she received the diploma and a prize recognition for being the top graded of her course.
The work has resulted from a collaboration between the ICMAB, the CNM and the company Dropsens.
Screen-printed electrodes made of a bismuth nanoparticle porous carbon nanocomposite material applied to the detection of heavy metals (Pengfei Niu, César Fernández-Sánchez,* Martí Gich,* Carla Navarro-Hernández, Pablo Fanjul-Bolado, and Anna Roig, Microchimica Acta, , Volume 183, Issue 2, pp 617-623).
This work reports on the simplified fabrication and on the characterization of bismuth-based screen-printed electrodes (SPEs) for use in heavy metal detection. A nanocomposite consisting of bismuth nanoparticles and amorphous carbon was synthesized by a combined one-step sol-gel and pyrolysis process and milled down to a specific particle size distribution as required for the preparation of an ink formulation to be used in screen printing. The resulting electrochemical devices were applied to the detection of Pb(II) and Cd(II) ions in water samples.
The porous structure of carbon and the high surface area of the bismuth nanoparticles allow for the detection of Pb(II) and Cd(II) at concentration levels below 4 ppb. The application of the SPEs was demonstrated by quantifying these ions in tap drinking water and wastewater collected from an influent of an urban wastewater treatment plant.
NanoBio&Med 2015 to be held in Barcelona 18-20 Nov is going to present the most recent international developments in the field of Nanobiotechnology and Nanomedicine and will provide a platform for multidisciplinary communication, new cooperations and projects to participants from both science and industry. Emerging and future trends of the converging fields of nanotechnology, biotechnology and medicine will be discussed among industry, academia, governmental and non-governmental institutions.
Anna will talk on the bio-identity of albumin-iron oxide nanoparticles on the 19th Nov at 16:20 h.
Dr. Maria Alejandra Ortega graduated with a thesis in “Development and validation of an optofluidic ultra-sensitive platform for specific and selective detection of relevant tumor markers in oncology” at the The Institute of Photonic Sciences (ICFO).