Hot off the press: new review about bacterial nanocellulose to treat epithelial tissues

We are happy to announce that our new review “Opportunities of Bacterial Cellulose to Treat Epithelial Tissues” is out and ready to download! This paper has been published on the journal “Current Drug Targets” on a special issue dedicated to Nanotechnology in Biomedical Applications. Do not miss this nice summary about the promising diverse applications of bacterial nanocellulose in regenerative medicine!

Hot off the press: published article on Energy & Environmental Science!

The beginning of 2019 has been fruitful in terms of publications for the N&N group! Last 22nd January 2019 the article “Farming thermoelectric paper” was published on Energy & Environmental Science. This study has been carried out in collaborations with the NanOpto group at ICMAB. Congratulations to all the authors for this multidisciplinary work!

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Hot off the press: published paper on Nanoscale Horizons!

Our new publication Nanocellulose films with multiple functional nanoparticles in confined spatial distribution is already out! This work has been published on Nanoscale Horizons and describes a laminated multifunctional bacterial cellulose nanocomposite. Congratulations to all the authors for this original piece of work!

Nanocellulose films with multiple functional nanoparticles in confined spatial distribution

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Hot off the press: published paper on Nanoscale!

The paper entitled “Nanoclusters of crystallographically aligned nanoparticles for magnetic thermotherapy: aqueous ferrofluid, agarose phantoms and ex vivo melanoma tumour assessment” has recently been published on the Nanoscale Journal. We congratulate Anna Roig and our collaborator Marcela Fernández for being authors of this nice study!


Abstract: Magnetic hyperthermia is an oncological therapy where magnetic nanostructures, under a radiofrequency field, act as heat transducers increasing tumour temperature and killing cancerous cells. Nanostructure heating efficiency depends both on the field conditions and on the nanostructure properties and mobility inside the tumour. Such nanostructures are often incorrectly bench-marketed in the colloidal state and using field settings far off from the recommended therapeutic values. Here, we prepared nanoclusters composed of iron oxide magnetite nanoparticles crystallographically aligned and their specific absorption rate (SAR) values were calorimetrically determined in physiological fluids, agarose-gel-phantoms and ex vivo tumours extracted from mice challenged with B16-F0 melanoma cells. A portable, multipurpose applicator using medical field settings; 100 kHz and 9.3 kA m−1, was developed and the results were fully analysed in terms of nanoclusters’ structural and magnetic properties. A careful evaluation of the nanoclusters’ heating capacity in the three milieus clearly indicates that the SAR values of fluid suspensions or agarose-gel-phantoms are not adequate to predict the real tissue temperature increase or the dosage needed to heat a tumour. Our results show that besides nanostructure mobility, perfusion and local thermoregulation, the nanostructure distribution inside the tumour plays a key role in effective heating. A suppression of the magnetic material effective heating efficiency appears in tumour tissue. In fact, dosage had to be increased considerably, from the SAR values predicted from fluid or agarose, to achieve the desired temperature increase. These results represent an important contribution towards the design of more efficient nanostructures and towards the clinical translation of hyperthermia.

Hot off the press: Published paper in Nature Communications!

We are happy to announce that last 1st of November 2018, the paper “Stability and nature of the volume collapse of ε-Fe2O3 under extreme conditions” was published on the journal Nature Communications. This study is co-authored by the permanent researcher at the N&N group Martí Gich.


Abstract: Iron oxides are among the major constituents of the deep Earth’s interior. Among them, the epsilon phase of Fe2O3 is one of the less studied polymorphs and there is a lack of information about its structural, electronic and magnetic transformations at extreme conditions. Here we report the precise determination of its equation of state and a deep analysis of the evolution of the polyhedral units under compression, thanks to the agreement between our experiments and ab-initio simulations. Our results indicate that this material, with remarkable magnetic properties, is stable at pressures up to 27 GPa. Above 27 GPa, a volume collapse has been observed and ascribed to a change of the local environment of the tetrahedrally coordinated iron towards an octahedral coordination, finding evidence for a different iron oxide polymorph. DOI:


Congratulations Martí!

Hot off the press! Published paper on The Chemical Record

Congratulations to the authors Martí Gich, Anna Roig (N&N group), Pengfei Niu (former member of the N&N group) and César Fernández‐Sánchez (N&N collaborator form the Barcelona Institute of Microelectronics) for their published paper “Metal Nanoparticle Carbon Gel Composites in Environment in Water Sensing Applications”. The manuscript was published in the journal Chemical Record in a special issue dedicated to Prof. Ruiz-Hitzky.


Abstract: The synthesis of organic‐inorganic nanocomposites that can interact with different environmental pollutants and can be mass‐produced are very promising materials for the fabrication of chemical sensor devices. Among them, metal (or metal oxide) nanoparticles doped conductive porous carbon composites can be readily applied to the production of electrochemical sensors and show enhanced sensitivity for the measurement of water pollutants, thanks to the abundant accessible and functional sites provided by the interconnected porosity and the metallic nanoparticles, respectively. In this personal account, an overview of several synthesis routes of porous carbon composites containing metallic nanoparticles is given, paying special attention to those based on sol‐gel techniques. These are very powerful to synthesize hybrid porous materials that can be easily processed into powders and thin films, so that they can be implemented in electrode fabrication processes based on screen‐printing and lithography techniques, respectively. We emphasize the sol‐gel routes developed in our group for the synthesis of bismuth or gold nanoparticle doped porous carbon composites applied to fabricate electrochemical sensors that can be scaled down to produce miniaturized on‐chip sensing devices for the sensitive detection of heavy metal pollutants in water. The trend towards the miniaturization of electrochemical sensors to be readily employed as analytical tools in environmental monitoring follow the market requirements of rapid and accurate on‐site analysis, small sample consumption and waste production, as well as potential for continuous or semi‐continuous in‐situ determination of a wide variety of target analytes.

New paper from the group!

Congratulations to Anna LaromaineAnna Roig and their collaborators from the Karlsruhe Institute of Technology Tina Tronser (first author) and Pavel A. Levkin for their new paper: Bacterial Cellulose Promotes Long-Term Stemness of mESC! This manuscript was published on ACS Applied Materials and Interfaces the 20th of April 2018.  


Abstract: Stem cells possess unique properties, such as the ability to self-renew and the potential to differentiate into an organism’s various cell types. These make them highly valuable in regenerative medicine and tissue engineering. Their properties are precisely regulated in vivo through complex mechanisms that include multiple cues arising from the cell interaction with the surrounding extracellular matrix, neighboring cells, and soluble factors. Although much research effort has focused on developing systems and materials that mimic this complex microenvironment, the controlled regulation of differentiation and maintenance of stemness in vitro remains elusive. In this work, we demonstrate, for the first time, that the nanofibrous bacterial cellulose (BC) membrane derived from Komagataeibacter xylinus can inhibit the differentiation of mouse embryonic stem cells (mESC) under long-term conditions (17 days), improving their mouse embryonic fibroblast (MEF)-free cultivation in comparison to the MEF-supported conventional culture. The maintained cells’ pluripotency was confirmed by the mESCs’ ability to differentiate into the three germ layers (endo-, meso-, and ectoderm) after having been cultured on the BC membrane for 6 days. In addition, the culturing of mESCs on flexible, free-standing BC membranes enables the quick and facile manipulation and transfer of stem cells between culture dishes, both of which significantly facilitate the use of stem cells in routine culture and various applications. To investigate the influence of the structural and topographical properties of the cellulose on stem cell differentiation, we used the cellulose membranes differing in membrane thickness, porosity, and surface roughness. This work identifies bacterial cellulose as a novel convenient and flexible membrane material enabling long-term maintenance of mESCs’ stemness and significantly facilitating the handling and culturing of stem cells.


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