We congratulate the autos Laura Gonzalez-Moragas, Si-Ming Yu, Núria Benseny-Cases, Stephen Stürzenbaum, Anna Roig and Anna Laromaine for their recently accepted paper: Toxicogenomics of iron oxide nanoparticles in the nematode C. elegans. This research arises from a collaboration of the N&N group, the ALBA Synchrotron Light Source (MIRAS line) and the King’s College London.
Here you can read the abstract of the paper:
We present a mechanistic study of the effect of iron oxide nanoparticles (SPIONs) in C. elegans combining a genome-wide analysis with the investigation of specific molecular markers frequently linked to nanotoxicity. The effects of two different coatings were explored: citrate, an anionic stabilizer, and bovine serum albumin, as a pre-formed protein corona. The transcriptomic study identified differentially expressed genes following an exposure to SPIONs. The expression of genes involved in oxidative stress, metal detoxification response, endocytosis, intestinal integrity and iron homeostasis was quantitatively evaluated. The role of oxidative stress was confirmed by gene expression analysis and by synchrotron Fourier Transform infrared microscopy based on the higher tissue oxidation of NP-treated animals. The observed transcriptional modulation of key signaling pathways such as MAPK and Wnt suggests that SPIONs might be endocytosed by clathrin-mediated processes, a putative mechanism of nanotoxicity which deserves further mechanistic investigations.
Toxicogenomics of iron oxide nanoparticles in the nematode C. elegans
Laura Gonzalez-Moragas, Si-Ming Yu, Núria Benseny-Cases, Stephen Stürzenbaum, Anna Roig and Anna Laromaine
Nanotoxicology, Accepted manuscript online: 15 Jun 2017. DOI: 10.1080/17435390.2017.1342011
Good job! 🙂