El projecte“Nanopartículas sintéticas como tratamiento innovador en la sepsis (SPRINT-4-SEPSIS)” serà finançat per la Fundación Ramón Areces en el marc del XIX Concurso Nacional de Ayudas a la Investigación en Ciencias de la Vida y de la Materia.
Abstract: Magnetic hyperthermia is an oncological therapy where magnetic nanostructures, under a radiofrequency field, act as heat transducers increasing tumour temperature and killing cancerous cells. Nanostructure heating efficiency depends both on the field conditions and on the nanostructure properties and mobility inside the tumour. Such nanostructures are often incorrectly bench-marketed in the colloidal state and using field settings far off from the recommended therapeutic values. Here, we prepared nanoclusters composed of iron oxide magnetite nanoparticles crystallographically aligned and their specific absorption rate (SAR) values were calorimetrically determined in physiological fluids, agarose-gel-phantoms and ex vivo tumours extracted from mice challenged with B16-F0 melanoma cells. A portable, multipurpose applicator using medical field settings; 100 kHz and 9.3 kA m−1, was developed and the results were fully analysed in terms of nanoclusters’ structural and magnetic properties. A careful evaluation of the nanoclusters’ heating capacity in the three milieus clearly indicates that the SAR values of fluid suspensions or agarose-gel-phantoms are not adequate to predict the real tissue temperature increase or the dosage needed to heat a tumour. Our results show that besides nanostructure mobility, perfusion and local thermoregulation, the nanostructure distribution inside the tumour plays a key role in effective heating. A suppression of the magnetic material effective heating efficiency appears in tumour tissue. In fact, dosage had to be increased considerably, from the SAR values predicted from fluid or agarose, to achieve the desired temperature increase. These results represent an important contribution towards the design of more efficient nanostructures and towards the clinical translation of hyperthermia.
On Monday, July 16, 2018, the first ICMAB-CRAG meeting took place at CRAG. The goal of this meeting was to promote new collaborations among researchers from the ICMAB and the CRAG.
Anna Laromaine, who already collaborates with CRAG with the project “Plant nano-healing“, gave an overview about the C.elegans and the bacterial cellulose research lines in the N&N group. Later, Anna Roig presented the library of nanoparticles and its diverse applications that the N&N group has developed in the recent years.
Today we introduce the latest entry at the N&N group: the master’s student Oriol Torrecilla: “Hi, my name is Oriol Torrecilla and I am from Barcelona, Spain. In 2015 I got my B.Sc. in Nanoscience and Nanotechnology at Autonomous University of Barcelona (UAB). I spent half a year in Denmark doing my bachelor’s thesis at the iNANO center. After I received my degree, I worked at ICMAB on synthesis and functionalization of gold nanoparticles in the FunNanoSurf group. Right now I am studying a Master’s degree in Applied Material Chemistry at UB and I will be doing my thesis in the N&N group with Ana Larromaine and Soledad Roig. My project is about synthesis and characterization of cellulose spheres functionalized with different nanoparticles which have promising applications, especially in biomedicine.”
Welcome to the group Oriol, we hope you enjoy your time here!
Lyon 10th October. Anna Roig participated in the 11th Collaborative Day of Lyonbiopôle organized by Lyonbiopôle, with the support of Biocat.
This 11th Collaborative Day where Anna participated aims at promoting R&D partnerships and catalyze the emergence of new tools for the prevention, diagnosis and treatment of pathologies. The day gives a framework to discuss the major challenges in the medical field, technological & scientific advances and to design partnerships and innovation projects to improve the management of diseases. This year more than 300 participants were registered.
In the morning, thematic roundtables took place, gathering around 20 persons each one from SMEs, research, industry, hospitals to brainstorm. The purpose of these is to support emergence of discussions and potential ideas of collaborations. A dedicated brainstorm methodology to stir the discussion is used. Anna Roig chaired the round table TR14: Use of nanoparticles in targeted therapies: what added value?
In the afternoon, blue sky meetings gave the opportunity to 10 SMEs to present their innovative technology looking for strategic collaborations and 10 project leaders to present their R&D project idea looking for partners.
Abstract: Understanding the in vivo fate and transport of nanoparticles (NPs) is challenging, but critical. We review recent studies of metal and metal oxide NPs using the model organism Caenorhabditis elegans, summarizing major findings to date. In a joint transdisciplinary effort, we highlight underutilized opportunities offered by powerful techniques lying at the intersection of mechanistic toxicology and materials science. To this end, we firstly summarize the influence of exposure conditions (media, duration, C. elegans lifestage) and NP physicochemical properties (size, coating, composition) on the response of the worm to NP treatment.
Next, we focus on the techniques employed to study NP entrance route, uptake, biodistribution and fate, emphasizing the potential of extending the toolkit available with novel and powerful techniques. Next, we review findings on several NP-induced biological responses, namely transport routes and altered molecular pathways, and illustrate the molecular biology and genetic strategies applied, critically reviewing their strengths and weaknesses.
Finally, we advocate the incorporation of a set of minimal materials and toxicological science experiments that will permit meta-analysis and synthesis of multiple studies in the future. We believe this review will facilitate coordinated integration of both well-established and underutilized approaches in mechanistic toxicology and materials science by the nanomaterials research community
Citation: L. Gonzalez-Moragas, L. L. Maurer, V. M. Harms, J. Meyer, A. Laromaine and A. Roig, Mater. Horiz., 2017, DOI: 10.1039/C7MH00166E
On May 2nd Anna Laromaine was invited by Prof. Ventura Lab to give a talk in their facilities. The Group of NatasciaVentura uses C. elegans as a screening tool to unravel molecular mechanisms of mitochondrial-stress, with special attention paid to the cross-talk between genetic and environmental interventions.
As we announced before, on Friday 21st of April Miquel Torras received his Sant Jordi Price 2017 at the IEC: Institut d’Estudis Catalans.
The ceremony took place at the Prat de la Riba hall with the presence of Joandomènec Ros, president of the IEC, Jana Balacciu winner of the international price Catalònia and Carme Forcadell the president of the Catalan Parliment.
Miquel received two prices: one from the Catalan Society of Chemistry and a recognition from the Catalan Society of Physics.
Here Miquel says a word of thanks to the IEC and those how supported his work:
Benvolguts companys i amics, m’és difícil expressar l’emoció que he sentit i continuo sentint pel fet d’haver estat multi premiat als premis Sant Jordi 2017, però puc dir que veig recompensat l’esforç dedicat, provant que la bona feina i el treball rigorós són finalment reconeguts.
M’agradaria tornar a agrair els premis a l’Institut d’Estudis Catalans, i a les Societats Catalanes de Química i de Física. És el meu desig estar-ne a l’altura continuant aportant quelcom a la ciència (i a la ciència en català). També vull compartir-los amb vosaltres, ja que han estat possibles amb la vostra col·laboració i ajuts. Moltes gràcies!
In this week’s Group Meeting we welcomed Olatz Arriaga, an undergraduate student from the Basque Country. Olatz is studying “Nanoscience and Nanotechnology” at the Universitat Autònoma de Barcelona (UAB), and will do her Final Bachelor’s Project under the supervision of Anna Roig, working in the synthesis of gold and titanium oxide nanoparticles.
We also said goodbye to Dani Beltran and Valentin Natarov, who are leaving this week the ICMAB. Dani will continue his Master in Biomedical Engineering at UB-UPC, and Valentin will go back to Belarus to continue his Master in Chemistry at Belarusian State University.
They both gave a very nice presentation on the work they have been doing in our group, about stabilizing non-stable polymorphs in mesoporous silica, and synthesizing iron oxide and silica nanocomposites for biomedical applications, under the supervision of Martí Gich and Anna Roig.